Day 46 of My Journey from 64 to 65 ProArgi9+ Health Benefits Part 2


The following report highlights health benefits of increased L-arginine in the human body, backed by published research.  L-arginine is a semi-essential amino acid produced in the liver and kidneys.  It is found in protein-rich foods like red meat.  Medical research has now shown that supplementation with adequate amounts of  L-arginine facilitates the following:

Yesterday we looked at the first two of these, The Aging Process and The Cardiovascular System. Today I will cover The Digestive System, The Excretory System and the Immune System which given the Pandemic #Covid-19 is something that we should all be looking after better than we do. As I mentioned yesterday, this is based on research carried out by the people listed at the end of this article on L-Arginine who are much more qualified than I am. My job is to research articles and give the best information I can so that you will #lookharder, ask questions and know more about why ProArgi9+ is probably the best food supplement available today anywhere in the world. Clinically proven to produce the correct amount of Nitric Oxide over an extended period of time which is a great benefit to those that take ProArgi9+ on a daily basis.

Digestive System

  • In the digestive system, L-arginine:
  • deficiency can cause constipation.
  • supplementation may decrease the incidence of gallstones.
  • reduces interstitial permeability. (24)
  • alleviates many cases of ulcerative colitis (by promoting the healing of ulcers that occur in the colon of ulcerative colitis patients). (25)
  • may improve irritable bowel syndrome (IBS). (26)
  • reduces ulcers. (27)
  • helps prevent post surgical damage after intestinal manipulation (28).
  • improves outcome in sepsis. (29)

Excretory System

In the excretory system, L-arginine:

  • aleviates the pain and discomfort associated with interstitial cystitis. (30)
  • significantly improves the function of the kidneys and helps to prevent age-related degradation of the kidneys. (31)

Immune System

In the immune system, L-arginine:

  • helps to prevent bacterial and viral diseases in persons with suppressed immune systems. (32)
  • blocks the formation of some forms of cancer (inhibits cellular replication of 24 different types of cancer in animals). (33)
  • boosts the ability of the immune system to fight breast cancer. (34)
  • lowers tumor protein synthesis and tumor growth rate in liver cancer. (35)
  • inhibits the further growth of some types of sarcomas. (36)
  • improves outcome of cancer treatment. (37)
  • (in non-excessive quantities) stimulates numerous aspects of the immune system. (38)
  • stimulates the production of helper T-cells. (39)
  • stimulates activity and production of lymphocytes by the thymus gland. (40)
  • increases the activity (cytotoxicity) of NK lymphocytes. (41)
  • stimulates the production of T-lymphocytes within the thymus and makes them more active and effective. (42)
  • increases the size of the thymus, stimulates the production of lymphocytes and restores the production of thymosin to youthful levels. (43)
  • helps to counteract inflammation. (44)
  • accelerates the ability of the immune system to recover from surgery. (45)
  • improves sickle cell disease. (46)


  1. Radner, Wlk et al. Arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl) lysine in the aging NMRO-mouse. J Gerontol. 49(2): M44-M46, 1994.
  2. Gianotti, L., Macario, M., Lanfranco, F., et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab. 2000 Oct; 85(10): 3604-8.
  3. Ceremuzynski, L., et al. Effect of supplemental oral arginine on exercise capacity in patients with stable angina pectoris.  AM J Cardiol. 80:331-333, 1997.
  4. Adams, R., R., et al. Oral arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis, 1 29(2): 261-269, 1997.
  5. Adams, M., R., et al. Cigarette smoking is associated with increased human monocyte adhesion to endothelial cells: reversibility with oral arginine but not vitamin C. Journal of the American College of Cardiology. 29(3): 491-497, 1997.
  6. Huk, I., et al. Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemic/reperfusion injury in skeletal muscle. Circulation. 97:667-675, 1997.
  7. Drexler, H., et al. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by arginine. The Lancet. 338:1546-50, 1991.
  8. Huk, I., et al. Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation. 97:667-675, 1997.
  9. Kolfman, B., et al. Improvement of cardiac performance by intravenous infusion of l-arginine in patients with moderate congestive heart failure. Journal of the American College of Cardiology. 26(5): 1251-6, 1995.
  10. Quyyumi, A. Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? Journal of American College of Cardiology. 1998 Oct; 32(4): 904-11.
  11. Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
  12. Sisic, D., Francishetti, A., Frolich, E. Prolonged arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive and normal rats. Hypertension 1999 Jan; 33(1 Pt 2): 451-5.
  13. Nakaki, T., et al. Arginine induced hypotension. Lancet. 1990 Oct 20; 336(8721): 1016-7.
  14. Nagaya, N., et al. Short-term oral administration of arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. American Journal of Respiratory Critical Care Medicine. 163(4): 887-891, 2001.
  15. Roberts, A. et al. Nutraceuticals: The Complete Encyclopedia of Supplements, Herbs, Vitamins and Healing Foods. Berkely Publishing Group. New York, USA. 2001: 319.
  16. Maxwell, A., Anderson, B., Zapien, M., Cooke, J. Endothelial dysfunction in hypercholesterolemia is reversed by nutritional product designed to enhance nitric oxide activity. Cardiovascular Drugs Therapy. 2000 Jun; 14(3): 309-16.
  17. Maxwell, A., Anderson, B., Cooke, J. Nutritional therapy for peripheral artery disease. Vascular Medicine. 2000; 5(1): 11-19.
  18. Wallace, A., Ratcliffe, M., Galinez, D., Kong, J. Arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery. Anesthesiology. 1999 Jun; 90(6): 1 577-8.
  19. Bode-Boger, S. Boger, R., et al. Differential inhibition of human platelet aggregation and thromboxane A 2 formation by arginine in vivo and in vitro. Arch Pharmacology. 1998; 357: 143-150.
  20. Le Yorneau, T., Van Belle, E., Corseaux, D., et al. Role of nitric oxide in re-stenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit. Journal of American College of Cardiology. 1999 Mar; 33(3): 8876-82.
  21. Suematsu, Y., Ohtsuka, T., et al. Arginine given after ischemic preconditioning can enhance cardio protection in isolated rat hearts. European Journal of Cardiothoracic Surgery. 2001, Jun; 19(6): 873-9.
  22. Hambrecht, R., et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral arginine supplementation. Journal of American College of Cardiology. 2000 Mar 1; 35(3): 706-1 3.
  23. Bode-Boger, S., Boger, R., et al. Arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation. 1996 Jan 1; 93(1): 85-90.
  24. Miller, A., The pathogenesis, clinical implication, and treatment of intestinal hyperpermeability. Alternative Medicine Review. 2(5): 330-345, 1997.
  25. Segala, M. (editor). Disease Prevention and Treatment 3rd Life Extension Media. Florida, USA, 2000; 202.
  26. Sahin A., Atalik, K., Gunel, E., Dogan, N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+ channels in these responses. Methods Find Ex Clin Pharmacol. 2001 Jan-Feb; 23(1): 13-7.
  27. Khattab, M., Gad, M., Abdallah, D. Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res. 2001 May; 43(5): 463-7.
  28. Thomas, S., Ramachandran A., Patra, S., et al. Nitric oxide protects the intestine from the damage induced by laparotomy and gut manipulation. Journal of Surg Res. 2001 Jul; 99(1): 25-32.
  29. Vallet, B. Microthrombosis in sepsis. Minerva Anesthesiol. 2001 Apr; 67(4): 298-301.
  30. Smith, S., et al. Improvement in interstitial cystitis symptoms scores during treatment with oral arginine. Journal of Urology. 158(3 Part 1): 703-708, 1997.
  31. Reckelhoff, J., et al. Long-term dietary supplementation with L-arginine prevents age-related reduction in renal function. American Journal of Physiology. 272 (6 Part 2): R1 768-R1 774, 1997.
  32. Field, C., et al. Glutamine and arginine: immunonutrients for improved health. Med Sci Sports Exerc. 32LSuppl) S377-88, 2000.
  33. Reynolds, J., et al. Immunologic effects of arginine supplementation in tumor-bearing and non-tumor-bearing hosts. Annals of Surgery. 211:202-209, 19.
  34. Cha-Chung, Y. Arrest of mammary tumor growth by L-arginine. Biochemical and Biophysical Research Communications. 95:1306-1313, 1980.
  35. Weisburger, J. Prevention by arginine glutamate of the carcinogenicity of acetamide in rates. Toxicology and Applied Pharmacology. 14: 163-175, 1969.
  36. Rettura, G., et al. Supplemental arginine increases thymis cellularity in normal and murine sarcoma virus-inoculated mice and increases the resistance to murine sarcoma virus tumour. J Par Ent Nutr. 3: 409-416, 1979.
  37. Heys, D., et al. Dietary supplementation with L-arginine: Modulation of tumor infiltrating lymphocytes in patients with colorectal cancer. British Journal of Surgery. 1997 Feb; 84(2): 238-41.
  38. Kirk, S., et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery. 11 4(2): 155-159, 1993.
  39. Blechman, S., et al. L-arginine boosts the immune system. Muscular Development. 38(10): 72, 2001.
  40. Barbul, A., et al. Arginine stimulates lymphocyte immune response in health human beings. Surgery. 90: 224-251, 1981.
  41. Ochoa, J., et al. Effects of L-arginine on the proliferation of T lymphocyte subpopulations. Journal of Parenteral Enteral Nutrition. 25: 23-29, 2001.
  42. Moriguchi, S., et al. Functional changes in human lymphocytes and monocytes after in vitro incubation with arginine. Nutrition Research. 7: 719-729, 1987.
  43. Dean, W. The neuroendocrine theory of aging part IV: the immune homeostat. Vitamin Research News. October 1999.
  44. Efron, D., et al. Modulation of inflammation and immunity by arginine supplements. Curr Opin Clin Nutr Metab Care. 1: 531-538, 1998.
  45. Wilmore, D., The effect of glutamine supplementation in patients following elective surgery and accidental injury. Journal of Nutrition. 131 (9 Supplement): 2543S-2549S, 2001.
  46. Morric, C., Kuypers, F., et al. Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome. Journal of Ped Hemat/Onc. 2000 Nov-Dec; 22(6): 5-20.

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