Day 46 of My Journey from 64 to 65 ProArgi9+ Health Benefits Part 2
HEALTH BENEFITS OF L-ARGININE – SCIENTIFIC RESEARCH INCLUDED
The following report highlights health benefits of increased L-arginine in the human body, backed by published research. L-arginine is a semi-essential amino acid produced in the liver and kidneys. It is found in protein-rich foods like red meat. Medical research has now shown that supplementation with adequate amounts of L-arginine facilitates the following:
Yesterday we looked at the first two of these, The Aging Process and The Cardiovascular System. Today I will cover The Digestive System, The Excretory System and the Immune System which given the Pandemic #Covid-19 is something that we should all be looking after better than we do. As I mentioned yesterday, this is based on research carried out by the people listed at the end of this article on L-Arginine who are much more qualified than I am. My job is to research articles and give the best information I can so that you will #lookharder, ask questions and know more about why ProArgi9+ is probably the best food supplement available today anywhere in the world. Clinically proven to produce the correct amount of Nitric Oxide over an extended period of time which is a great benefit to those that take ProArgi9+ on a daily basis.
- In the digestive system, L-arginine:
- deficiency can cause constipation.
- supplementation may decrease the incidence of gallstones.
- reduces interstitial permeability. (24)
- alleviates many cases of ulcerative colitis (by promoting the healing of ulcers that occur in the colon of ulcerative colitis patients). (25)
- may improve irritable bowel syndrome (IBS). (26)
- reduces ulcers. (27)
- helps prevent post surgical damage after intestinal manipulation (28).
- improves outcome in sepsis. (29)
In the excretory system, L-arginine:
- aleviates the pain and discomfort associated with interstitial cystitis. (30)
- significantly improves the function of the kidneys and helps to prevent age-related degradation of the kidneys. (31)
In the immune system, L-arginine:
- helps to prevent bacterial and viral diseases in persons with suppressed immune systems. (32)
- blocks the formation of some forms of cancer (inhibits cellular replication of 24 different types of cancer in animals). (33)
- boosts the ability of the immune system to fight breast cancer. (34)
- lowers tumor protein synthesis and tumor growth rate in liver cancer. (35)
- inhibits the further growth of some types of sarcomas. (36)
- improves outcome of cancer treatment. (37)
- (in non-excessive quantities) stimulates numerous aspects of the immune system. (38)
- stimulates the production of helper T-cells. (39)
- stimulates activity and production of lymphocytes by the thymus gland. (40)
- increases the activity (cytotoxicity) of NK lymphocytes. (41)
- stimulates the production of T-lymphocytes within the thymus and makes them more active and effective. (42)
- increases the size of the thymus, stimulates the production of lymphocytes and restores the production of thymosin to youthful levels. (43)
- helps to counteract inflammation. (44)
- accelerates the ability of the immune system to recover from surgery. (45)
- improves sickle cell disease. (46)
- Radner, Wlk et al. Arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl) lysine in the aging NMRO-mouse. J Gerontol. 49(2): M44-M46, 1994.
- Gianotti, L., Macario, M., Lanfranco, F., et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab. 2000 Oct; 85(10): 3604-8.
- Ceremuzynski, L., et al. Effect of supplemental oral arginine on exercise capacity in patients with stable angina pectoris. AM J Cardiol. 80:331-333, 1997.
- Adams, R., R., et al. Oral arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis, 1 29(2): 261-269, 1997.
- Adams, M., R., et al. Cigarette smoking is associated with increased human monocyte adhesion to endothelial cells: reversibility with oral arginine but not vitamin C. Journal of the American College of Cardiology. 29(3): 491-497, 1997.
- Huk, I., et al. Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemic/reperfusion injury in skeletal muscle. Circulation. 97:667-675, 1997.
- Drexler, H., et al. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by arginine. The Lancet. 338:1546-50, 1991.
- Huk, I., et al. Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation. 97:667-675, 1997.
- Kolfman, B., et al. Improvement of cardiac performance by intravenous infusion of l-arginine in patients with moderate congestive heart failure. Journal of the American College of Cardiology. 26(5): 1251-6, 1995.
- Quyyumi, A. Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? Journal of American College of Cardiology. 1998 Oct; 32(4): 904-11.
- Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
- Sisic, D., Francishetti, A., Frolich, E. Prolonged arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive and normal rats. Hypertension 1999 Jan; 33(1 Pt 2): 451-5.
- Nakaki, T., et al. Arginine induced hypotension. Lancet. 1990 Oct 20; 336(8721): 1016-7.
- Nagaya, N., et al. Short-term oral administration of arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. American Journal of Respiratory Critical Care Medicine. 163(4): 887-891, 2001.
- Roberts, A. et al. Nutraceuticals: The Complete Encyclopedia of Supplements, Herbs, Vitamins and Healing Foods. Berkely Publishing Group. New York, USA. 2001: 319.
- Maxwell, A., Anderson, B., Zapien, M., Cooke, J. Endothelial dysfunction in hypercholesterolemia is reversed by nutritional product designed to enhance nitric oxide activity. Cardiovascular Drugs Therapy. 2000 Jun; 14(3): 309-16.
- Maxwell, A., Anderson, B., Cooke, J. Nutritional therapy for peripheral artery disease. Vascular Medicine. 2000; 5(1): 11-19.
- Wallace, A., Ratcliffe, M., Galinez, D., Kong, J. Arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery. Anesthesiology. 1999 Jun; 90(6): 1 577-8.
- Bode-Boger, S. Boger, R., et al. Differential inhibition of human platelet aggregation and thromboxane A 2 formation by arginine in vivo and in vitro. Arch Pharmacology. 1998; 357: 143-150.
- Le Yorneau, T., Van Belle, E., Corseaux, D., et al. Role of nitric oxide in re-stenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit. Journal of American College of Cardiology. 1999 Mar; 33(3): 8876-82.
- Suematsu, Y., Ohtsuka, T., et al. Arginine given after ischemic preconditioning can enhance cardio protection in isolated rat hearts. European Journal of Cardiothoracic Surgery. 2001, Jun; 19(6): 873-9.
- Hambrecht, R., et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral arginine supplementation. Journal of American College of Cardiology. 2000 Mar 1; 35(3): 706-1 3.
- Bode-Boger, S., Boger, R., et al. Arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation. 1996 Jan 1; 93(1): 85-90.
- Miller, A., The pathogenesis, clinical implication, and treatment of intestinal hyperpermeability. Alternative Medicine Review. 2(5): 330-345, 1997.
- Segala, M. (editor). Disease Prevention and Treatment 3rd Life Extension Media. Florida, USA, 2000; 202.
- Sahin A., Atalik, K., Gunel, E., Dogan, N. Nonadrenergic, noncholinergic responses of the human colon smooth muscle and the role of K+ channels in these responses. Methods Find Ex Clin Pharmacol. 2001 Jan-Feb; 23(1): 13-7.
- Khattab, M., Gad, M., Abdallah, D. Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion. Pharmacol Res. 2001 May; 43(5): 463-7.
- Thomas, S., Ramachandran A., Patra, S., et al. Nitric oxide protects the intestine from the damage induced by laparotomy and gut manipulation. Journal of Surg Res. 2001 Jul; 99(1): 25-32.
- Vallet, B. Microthrombosis in sepsis. Minerva Anesthesiol. 2001 Apr; 67(4): 298-301.
- Smith, S., et al. Improvement in interstitial cystitis symptoms scores during treatment with oral arginine. Journal of Urology. 158(3 Part 1): 703-708, 1997.
- Reckelhoff, J., et al. Long-term dietary supplementation with L-arginine prevents age-related reduction in renal function. American Journal of Physiology. 272 (6 Part 2): R1 768-R1 774, 1997.
- Field, C., et al. Glutamine and arginine: immunonutrients for improved health. Med Sci Sports Exerc. 32LSuppl) S377-88, 2000.
- Reynolds, J., et al. Immunologic effects of arginine supplementation in tumor-bearing and non-tumor-bearing hosts. Annals of Surgery. 211:202-209, 19.
- Cha-Chung, Y. Arrest of mammary tumor growth by L-arginine. Biochemical and Biophysical Research Communications. 95:1306-1313, 1980.
- Weisburger, J. Prevention by arginine glutamate of the carcinogenicity of acetamide in rates. Toxicology and Applied Pharmacology. 14: 163-175, 1969.
- Rettura, G., et al. Supplemental arginine increases thymis cellularity in normal and murine sarcoma virus-inoculated mice and increases the resistance to murine sarcoma virus tumour. J Par Ent Nutr. 3: 409-416, 1979.
- Heys, D., et al. Dietary supplementation with L-arginine: Modulation of tumor infiltrating lymphocytes in patients with colorectal cancer. British Journal of Surgery. 1997 Feb; 84(2): 238-41.
- Kirk, S., et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery. 11 4(2): 155-159, 1993.
- Blechman, S., et al. L-arginine boosts the immune system. Muscular Development. 38(10): 72, 2001.
- Barbul, A., et al. Arginine stimulates lymphocyte immune response in health human beings. Surgery. 90: 224-251, 1981.
- Ochoa, J., et al. Effects of L-arginine on the proliferation of T lymphocyte subpopulations. Journal of Parenteral Enteral Nutrition. 25: 23-29, 2001.
- Moriguchi, S., et al. Functional changes in human lymphocytes and monocytes after in vitro incubation with arginine. Nutrition Research. 7: 719-729, 1987.
- Dean, W. The neuroendocrine theory of aging part IV: the immune homeostat. Vitamin Research News. October 1999.
- Efron, D., et al. Modulation of inflammation and immunity by arginine supplements. Curr Opin Clin Nutr Metab Care. 1: 531-538, 1998.
- Wilmore, D., The effect of glutamine supplementation in patients following elective surgery and accidental injury. Journal of Nutrition. 131 (9 Supplement): 2543S-2549S, 2001.
- Morric, C., Kuypers, F., et al. Patterns of arginine and nitric oxide in patients with sickle cell disease with vaso-occlusive crisis and acute chest syndrome. Journal of Ped Hemat/Onc. 2000 Nov-Dec; 22(6): 5-20.
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