Day 45 of My Journey from 64 to 65 ProArgi9+ Could be the missing link!

Could it be that ProArgi9+ is the missing link to better health and medicine’s best kept secret? Was one of the last sentences in my post from yesterday which I wrote around 6.30am. Later that night I had the privilege of being invited to an online seminar where the main speaker was Dr Jim Sandberg.

I have known Dr Jim, or I should say known of him and his amazing work for several years now. Around this time last year, I managed to get him to agree to do some three-way calls with me and during those calls got to know him well. Some of the topics Jim discussed on our calls and again last night convinced me even more that ProArgi9+ could very well be the missing link to better health. Over the next few weeks I’m going to reveal why I believe this to be true by providing fact based evidence on the ground breaking research that went into creating ProArgi9+ and the clinical studies that have been carried out to give the product it’s incredible reputation and why it now appears on the Cologne List, The Physicians’ Desk Reference  and why ProArgi9+ won two awards, one in Poland and one in London-Best in Class product and Best New product.

Some of the information that Dr Jim shared with me is based on scientific research which I have included should you wish to carry out your own research. Maybe quicker for you to just ask me by getting in touch through the site or on Twitter.


The following report highlights health benefits of increased L-arginine in the human body, backed by published research.  L-arginine is a semi-essential amino acid produced in the liver and kidneys.  It is found in protein-rich foods like red meat.  Medical research has now shown that supplementation with adequate amounts of  L-arginine facilitates the following:

Let’s take a look at the first two of these, The Aging Process and The Cardiovascular System

Aging Process

In the aging process, L-arginine:

  • inhibits one of the primary mechanisms of the aging process (cross-linking). (1)
  • Increases the release of human growth hormone (HGH) from the pituitary gland. (2)

Cardiovascular System

In the cardiovascular system, L-arginine:

  • improves blood circulation, exercise capability and facilitates vasodilation in angina patients. (3)
  • helps to prevent atherosclerosis and reduces the severity of existing atherosclerosis. (4)
  • inhibits the adhesion of monocytes to the endothelium (an underlying event in atherosclerosis). (5)
  • improves blood circulation by stimulating nitric oxide (NO) production. NO is an endogenous neurotransmitter that helps to prevent vasoconstriction, and which initiates vasodilation by relaxing the smooth muscle cells of the blood vessels. (6)
  • helps to prevent abnormal blood clotting (by stimulating the production of plasmin and by increasing vasodilation). (7)
  • helps to prevent free radicals-induced damage to the lining of blood vessels (by enhancing the production of nitric oxide in blood vessels). (8)
  • significantly increases stroke volume and cardiac output (without affecting heart rate) in congestive heart failure patients. It also increases vasodilation in congestive heart failure patients. (9)
  • reverses consequences of coronary heart disease. (10)
  • lowers blood pressure in some hypertension patients (by facilitating nitric oxide production and by inhibiting the angiotensin converting enzyme, ACE). (11)
  • reverses adverse effects of high blood pressure. (12)
  • decreases high blood pressure. (13)
  • reduces pulmonary blood pressure and improves blood circulation in pulmonary hypertension patients. (14)
  • increases walking distance in patients with intermittent claudication. (15)
  • restores normal endothelial function in hypercholesterolemia. (16)
  • improves walking distance in peripheral vascular disease. (17)
  • improves outcome after bypass surgery. (18)
  • reduces blood clots and strokes. (19)
  • helps prevent restenosis after angioplasty and bypass. (20)
  • may give protection against size of heart attack. (21)
  • improves heart failure. (22)
  • improves peripheral vascular disease. (23)


  1. Radner, Wlk et al. Arginine reduces kidney collagen accumulation and N-epsilon-(carboxymethyl) lysine in the aging NMRO-mouse. J Gerontol. 49(2): M44-M46, 1994.
  2. Gianotti, L., Macario, M., Lanfranco, F., et al. Arginine counteracts the inhibitory effect of recombinant human insulin-like growth factor I on the somatotroph responsiveness to growth hormone-releasing hormone in humans. J Clin Endocrinol Metab. 2000 Oct; 85(10): 3604-8.
  3. Ceremuzynski, L., et al. Effect of supplemental oral arginine on exercise capacity in patients with stable angina pectoris.  AM J Cardiol. 80:331-333, 1997.
  4. Adams, R., R., et al. Oral arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis, 1 29(2): 261-269, 1997.
  5. Adams, M., R., et al. Cigarette smoking is associated with increased human monocyte adhesion to endothelial cells: reversibility with oral arginine but not vitamin C. Journal of the American College of Cardiology. 29(3): 491-497, 1997.
  6. Huk, I., et al. Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemic/reperfusion injury in skeletal muscle. Circulation. 97:667-675, 1997.
  7. Drexler, H., et al. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by arginine. The Lancet. 338:1546-50, 1991.
  8. Huk, I., et al. Arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation. 97:667-675, 1997.
  9. Kolfman, B., et al. Improvement of cardiac performance by intravenous infusion of l-arginine in patients with moderate congestive heart failure. Journal of the American College of Cardiology. 26(5): 1251-6, 1995.
  10. Quyyumi, A. Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? Journal of American College of Cardiology. 1998 Oct; 32(4): 904-11.
  11. Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001.
  12. Sisic, D., Francishetti, A., Frolich, E. Prolonged arginine on cardiovascular mass and myocardial hemodynamics and collagen in aged spontaneously hypertensive and normal rats. Hypertension 1999 Jan; 33(1 Pt 2): 451-5.
  13. Nakaki, T., et al. Arginine induced hypotension. Lancet. 1990 Oct 20; 336(8721): 1016-7.
  14. Nagaya, N., et al. Short-term oral administration of arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. American Journal of Respiratory Critical Care Medicine. 163(4): 887-891, 2001.
  15. Roberts, A. et al. Nutraceuticals: The Complete Encyclopedia of Supplements, Herbs, Vitamins and Healing Foods. Berkely Publishing Group. New York, USA. 2001: 319.
  16. Maxwell, A., Anderson, B., Zapien, M., Cooke, J. Endothelial dysfunction in hypercholesterolemia is reversed by nutritional product designed to enhance nitric oxide activity. Cardiovascular Drugs Therapy. 2000 Jun; 14(3): 309-16.
  17. Maxwell, A., Anderson, B., Cooke, J. Nutritional therapy for peripheral artery disease. Vascular Medicine. 2000; 5(1): 11-19.
  18. Wallace, A., Ratcliffe, M., Galinez, D., Kong, J. Arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery. Anesthesiology. 1999 Jun; 90(6): 1 577-8.
  19. Bode-Boger, S. Boger, R., et al. Differential inhibition of human platelet aggregation and thromboxane A 2 formation by arginine in vivo and in vitro. Arch Pharmacology. 1998; 357: 143-150.
  20. Le Yorneau, T., Van Belle, E., Corseaux, D., et al. Role of nitric oxide in re-stenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit. Journal of American College of Cardiology. 1999 Mar; 33(3): 8876-82.
  21. Suematsu, Y., Ohtsuka, T., et al. Arginine given after ischemic preconditioning can enhance cardio protection in isolated rat hearts. European Journal of Cardiothoracic Surgery. 2001, Jun; 19(6): 873-9.
  22. Hambrecht, R., et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral arginine supplementation. Journal of American College of Cardiology. 2000 Mar 1; 35(3): 706-1 3.
  23. Bode-Boger, S., Boger, R., et al. Arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled study. Circulation. 1996 Jan 1; 93(1): 85-90.


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