Day 54 of My Journey from 64 to 65 Nitric Oxide and ProArgi9+

ProArgi9+ is part of both DNA tests available from Synergy WorldWide, The Energy Kit and the Purify Kit. However here is a little more science for you behind Nitric Oxide from a study published by the Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU.

I will include the link to the main article for those of you who wish to read about it in more detail. Why have I linked this article to ProArgi9+ is simply because there is absolutely no other L-Arginine supplement on the market that produces Nitric Oxide in the human body so effecteivels and has also been subject to several clinical studies which I have written about in previous blog posts. Here is an excerpt from the article.

The role of the nitric oxide pathway in brain injury and its treatment–from bench to bedside.


  • The nitric oxide synthase pathway plays a pivotal role in brain blood flow regulation.
  • Disruption to this pathway occurs after injury, and contributes to secondary insult.
  • Nitric oxide donor agents show promise as therapy for secondary brain injury.


Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This review summarises current evidence regarding the role of NO in the regulation of cerebral blood flow at rest, under physiological conditions, and after brain injury, focusing on subarachnoid haemorrhage, traumatic brain injury, and ischaemic stroke and following cardiac arrest. We also review the role of NO in the response to hypoxic insult in the developing brain. NO depletion in ischaemic brain tissue plays a pivotal role in the development of subsequent morbidity and mortality through microcirculatory disturbance and disordered blood flow regulation. NO derived from endothelial nitric oxide synthase (eNOS) appears to have neuroprotective properties. However NO derived from inducible nitric oxide synthase (iNOS) may have neurotoxic effects. Cerebral NO donor agents, for example sodium nitrite, appear to replicate the effects of eNOS derived NO, and therefore have neuroprotective properties. This is true in both the adult and immature brain. We conclude that these agents should be further investigated as targeted pharmacotherapy to protect against secondary brain injury.

Role of NO in regulation of cerebral blood flow.

The brain accounts for 20% of the body’s energy consumption despite only accounting for 2% of its mass. One of the major roles of the cerebral circulation is to supply oxygen to the brain tissues as neuronal activation requires large amounts of energy to regulate the ion fluxes that occur on depolarisation. Therefore, it is essential that cerebral blood flow (CBF) is tightly regulated. The NO signalling pathway plays a major role in the regulation of CBF at rest and during physiological and pathological stresses. Understanding the mechanisms behind the regulation of these processes may therefore give useful insights into the CBF changes that occur during cerebral injury. Two main mechanisms underlie the regulation of CBF at rest, autoregulation and neurovascular coupling. eNOS-NO plays a key role in autoregulation, whereas nNOS derived NO appears crucial for neurovascular coupling.

You can read the full article here.

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