Day 64 The Nitric Oxide Regulator ADMA

What is ADMA?

ADMA (asymmetric dimethylarginine) regulates rates of NITRIC OXIDE (NO) formation. The 1998 Nobel Prize was awarded for the discovery of the Nitric Oxide molecule in the Cardiovascular System. As the principal endogenous inhibitor of Nitric Oxide synthase (NOS), Nitric Oxide acts as a signal molecule in the regulation of cellular responses including endothelial vasodilation, the nervous system, as a weapon against infections, as a regulator of blood pressure and as a gatekeeper of vascular function to the organs. This causes a healthier and oxygenated, unrestricted flow of blood through the cardiovascular systems and means a healthier you. It can, in many cases, aid recovery from injury including, sprains, strains, tears and surgery.

Elevated levels of ADMA are a risk factor for:

  • Hypertension
  • Cardiovascular disease
  • Diabetes
  • Insulin resistance and metabolic syndrome
  • Renal failure
  • Erectile dysfunction

Interventions to lower ADMA include but are not limited to:

  • Increase exercise
  • Reduce oxidant stress
  • Increase antioxidant levels
  • Normalise l-arginine, folic acid, vitamin B12 & vitamin B6 and the sunshine vitamin D3

The perfect solution is to use a product such as ProArgi9+ combined with exercise, ten thousand steps per day and a of course healthier diet. All that said, how do you know what you are doing is simply the best for you as an individual? After all we are all different in my ways, our DNA is unique to each and every one of us, just like our fingerprints and the Pulsewave generated every time our heart beats. More of that later.

The good news is that to help you create your own personal roadmap to a healthier you, Synergy WorldWide have partnered with the leader in DNA testing Novogenia. #MyGeneticBody will give you a two-hundred-page report that will, for the first time, show you which foods to eat, what supplements to switch and ditch and one of our team will happily guide you through your personal report. To find out more just drop me a message here or send me a tweet and I will make sure I reply to the same day.


You don’t need to take my word on why it is simply the best supplement that money can buy, I can send you all the facts that substantiate that claim.

Lastly coming back to ADMA Dr. John P. Cooke the author of “The Cardiovascular Cure” wrote a study back in 2004 which you can read in full here. AHA JOURNALS

Here’s a snippet:

The traditional risk factors of hypercholesterolemia, hypertension, diabetes mellitus, and tobacco exposure identify a subset of patients at greater cardiovascular risk. A variety of clinical phenotypes, biochemical markers, and genetic polymorphisms have been proposed to explain the variance in risk not explained by the traditional factors. Notably, all of the traditional risk factors, as well as the great majority of new risk markers, are associated with endothelial vasodilator dysfunction.

Because the end points (endothelial dysfunction leading to plaque formation, progression, and rupture) are the same, it follows that diverse risk factors ultimately share common pathways(s) of pathobiology. We and others have provided evidence for a ubiquitous mechanism of endothelial pathobiology shared by all risk factors and markers examined to date. This mechanism of endothelial derangement is mediated by an endogenous inhibitor of nitric oxide synthase (NOS), a molecule known as asymmetrical dimethylarginine (ADMA). Risk factors impair endothelial vasodilator function by causing the accumulation of ADMA. Furthermore, by blocking NO generation, ADMA initiates and promotes processes involved in atherogenesis, plaque progression. and plaque rupture.

If you would like to know more about ProArgi9+ or ADMA, then please drop me a message. I can also send you a copy of our e-book on Nitric Oxide Therapy and recommend other reading including more information on #MyGenticBody.

The best way to reach me is on Twitter @CampbellB_Young


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